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Improvements in monitoring and control of processes will support the guarantee of AM technologies as useful replacement for real production. To understand their material-process-structure links, develop new methods to measure and assess interactions between material and processing technologies. By means of supporting the representation, presentation, and

evaluation of AM data, provide new criteria to assure part quality and consistency. Boost research projects to specify ide l ways for adding computer technologies including simulation and machine learning into AM Essential elements. Important building blocks including essential minerals are susceptible to supply risk in many advanced technologies supporting

America's energy output, defense technology, manufactured goods, and general economy. Many times, these materials have unique and difficult to replicate particular properties using other material systems. However, lack of a robust and dependable local manufacturing sector has led to some supply chain vulnerabilities To help provide a more consistent supply of

Essential minerals President Trump issued

Executive Order 13817, a Federal Strategy to Ensure Secure and Reliable Supplies of Critical Minerals Thirty-three Federal agencies reacted by creating a list of thirty-five minerals critical to the United States for which the supply chain is susceptible to disturbance.forty-four The assessment showed that production of many important minerals is concentrated in just a few

foreign countries, so posing a risk of price spikes and supply interruptions endangering our economy and national R&D is needed on the cost-effective processing and separation of critical materials, including critical minerals, which are quite similar chemically but have greatly different properties and so can be used in different applications. Concurrently needed

is materials research to find new ways to more successfully use these materials in present and future applications, reduce materials loss during manufacturing of down-stream components, and recycle and recover resources for reuse where appropriate. By increasing our capability to mine, process, refine, recycle, and substitute fairly priced critical resources,

several important national security projects rely on them. Advances in complementary metal oxide semiconductor (CMOS) technology provide local access to the most available treatments. Moreover crucial for allowing precision medicine and treatment of "orphan" diseases is this potential for small-scale production. Although philanthropic foundations

These programs guarantee material

availability to our manufacturers, therefore reducing our reliance on foreign suppliers Advance reasonably priced technology for separation and processing to cut production costs Where suitable, look at substitutes and material alternatives to reduce reliance on limited resources; likewise, design production processes imaginatively to generate the ability to recycle key national security issue since these medical countermeasures could be needed at times when

components Guarantee of Medical Product Availability through Local Productio Major national security and financial implications surround advanced manufacturing of biologics, drugs, devices, and other health-regulated pharmaceutical and biotechnology items. Based on direct sales and well paid jobs, one industry study estimates that the pharmaceutical sector and foreign supplies are not available. A scalable, responsive, reasonably priced, distributed

makers of medical devices directly increase the U.S. economy by over $1 trillion annually Thirty-five forty-five Apart from their direct contribution to the U.S. GDP, these industries also greatly indirectly support better public health outcomes more difficult to quantify The United States has to fully use present policies and encourage new projects to bridge gaps in the end-

To end innovation ecosystem for home

manufacturing of health-regulated products Research, measurements, and standards supporting pre-competitive, cross-cutting technologies to assist faster and more cost-effective development cycles help de-risking the shift of industry to a more flexibly scaled and modular infrastructure. These advances will provide more responsiveness of local manufacturing

capacity The technical objectives for this aim define low-cost distributed manufacturing; constant production; and biofabrication of tissue and organs Reasonably priced, dispersed manufacturing. Manufacturing of conventional, small molecule medications, including generic antimicrobial treatments and to a lesser extent, vaccines, has offshored largely to India and sophisticated therapies with greater complexity and commercial value. This creates a possible

aiming at global access to medicines in low-resourced countries are investing in more cost-effective manufacturing for drugs and biologics, there is need to push manufacturing innovation that strengthens the business drivers for domestic production of drugs and biologics with great public health value but low commercial value.safeguarding of security Asia as the U.S. pharmaceutical company has transitioned to biologically-produced

Conclution

rugs and biologics so all U.S. citizens have affordability answers another public health need.Boost domestic drug production capacity to provide reasonably priced, small-scale biologics and medication manufacturing capability, therefore lowering the likelihood of medicine shortages. Provide a faster manufacturing path from bench to clinic to help to assist the creation of novel medicines and technologies manufacture constantly. Tra Develop novel approaches to turn current "batch-centric" pharmaceutical production into a smoothly

integrated, continuous unit operations manufacturing model maintaining constant product quality Organs and tissues biofabricated. Leading in biotechnology and biofabrication technologies at the fundamental science and academic levels is the United States. creation of transppeatable tissue At the basic level, much progress has been made in biological additivmanufacturing that is, the precise placement of viable human cells for tissue

even if the manufacturing of artificial biological organs depends on the discovery of the fundamental biomolecular signaling mechanisms guiding cells to assemble into functioning organs integrating several cell types. Once these challenges are overcome, organ donation lists will be few and manesses Lead constantly in electronics des and social media; almost every sector of the economy depends on developments in semiconductor technology and